Calera and Alexei Degterev Molecular pathways involved in cell death after chemically induced DNA damage. 151 Johan Högberg, Ilona Silins and Ulla Stenius Chemical induced alterations in p53 signaling. 111 Andreas Luch On the impact of the molecule structure in chemical carcinogenesis. Ulrike Camenisch and Hanspeter Naegeli Role of DNA repair in the protection against genotoxic stress.

Arlt Genotoxicity: damage to DNA and its consequences. Wolfgang Dekant The role of biotransformation and bioactivation in toxicity. Nylander-French Physiologically based toxicokinetic models and their application in human exposure and internal dose assessment. Gilbert Historical milestones and discoveries that shaped the toxicology sciences. TFC ∞ Cover illustration: with friendly permission of Andreas Luch Cover design: Benjamin Blankenburg, Basel, Switzerland Box 133, CH-4010 Basel, Switzerland Part of Springer Science+Business Media Printed on acid-free paper produced from chlorine-free pulp. © 2009 Birkhäuser Verlag AG Basel – Boston – Berlin P.O.

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Library of Congress Control Number: 2008938291 Bibliographic information published by Die Deutsche Bibliothek Die Deutsche Bibliothek lists this publication in the Deutsche Nationalbibliografie detailed bibliographic data is available in the Internet at īirkhäuser Verlag AG, Basel – Boston – Berlin Molecular, Clinical and Environmental Toxicology Volume 1: Molecular Toxicology Edited by Andreas LuchĮditor Andreas Luch Federal Institute for Risk Assessment Thielallee 88-92 14195 Berlin Germany

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